View source for SPRY4

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''[[Sprouty protein|Protein sprouty]] homolog 4''' is a [[protein]] that in humans is encoded by the ''SPRY4'' [[gene]].<ref name="pmid16465403">{{cite journal | vauthors = Katoh Y, Katoh M | title = FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells | journal = International Journal of Molecular Medicine | volume = 17 | issue = 3 | pages = 529–32 | date = Mar 2006 | pmid = 16465403 | doi = 10.3892/ijmm.17.3.529 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81848}}</ref>
== Function ==
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).<ref name="entrez"/>
== Interactions ==
SPRY4 has been shown to [[Protein-protein interaction|interact]] with [[TESK1]].<ref name=pmid12027893>{{cite journal | vauthors = Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ | title = Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 | journal = European Journal of Biochemistry | volume = 269 | issue = 10 | pages = 2546–56 | date = May 2002 | pmid = 12027893 | doi = 10.1046/j.1432-1033.2002.02921.x | doi-access = free }}</ref>
== See also ==
*[[MAPK signaling pathway]]
*[[Ras subfamily]]
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D | title = Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping | journal = BMC Psychiatry | volume = 8 | pages = 11 | year = 2008 | pmid = 18298822 | pmc = 2268687 | doi = 10.1186/1471-244X-8-11 | doi-access = free }}
* {{cite journal | vauthors = Cabrita MA, Jäggi F, Widjaja SP, Christofori G | title = A functional interaction between sprouty proteins and caveolin-1 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 39 | pages = 29201–12 | date = Sep 2006 | pmid = 16877379 | doi = 10.1074/jbc.M603921200 | doi-access = free }}
* {{cite journal | vauthors = Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B | title = Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer | journal = The Prostate | volume = 66 | issue = 6 | pages = 613–24 | date = May 2006 | pmid = 16388505 | doi = 10.1002/pros.20353 | s2cid = 43803094 | doi-access = free }}
* {{cite journal | vauthors = Ding W, Bellusci S, Shi W, Warburton D | title = Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 287 | issue = 1 | pages = L52-9 | date = Jul 2004 | pmid = 14977631 | doi = 10.1152/ajplung.00430.2003 }}
* {{cite journal | vauthors = Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A | title = Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 | journal = Nature Cell Biology | volume = 5 | issue = 5 | pages = 427–32 | date = May 2003 | pmid = 12717443 | doi = 10.1038/ncb978 | s2cid = 33846459 }}
* {{cite journal | vauthors = Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ | title = Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 | journal = European Journal of Biochemistry | volume = 269 | issue = 10 | pages = 2546–56 | date = May 2002 | pmid = 12027893 | doi = 10.1046/j.1432-1033.2002.02921.x | doi-access = free }}
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== External links ==
* [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q9C004 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)
[[Category:SPR domain]]
[[Category:Human proteins]]
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