View source for SUZ12

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Polycomb protein SUZ12''' is a [[protein]] that in humans is encoded by the ''SUZ12'' [[gene]].<ref name="pmid8590280">{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = August 1995 | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 | doi-access = free | citeseerx = 10.1.1.333.6945 }}</ref><ref name="pmid11371647">{{cite journal | vauthors = Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J | title = Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 11 | pages = 6348–53 | date = May 2001 | pmid = 11371647 | pmc = 33471 | doi = 10.1073/pnas.101132598 | bibcode = 2001PNAS...98.6348K | doi-access = free }}</ref><ref name="pmid18784248">{{cite journal | vauthors = Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB | title = Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development | journal = Reproduction | volume = 136 | issue = 6 | pages = 777–85 | date = December 2008 | pmid = 18784248 | doi = 10.1530/REP-08-0045 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23512}}</ref>
== Function ==
This zinc finger gene has been identified at the breakpoints of a recurrent [[chromosomal translocation]] reported in endometrial stromal sarcoma. [[Genetic recombination|Recombination]] of these breakpoints results in the fusion of this gene and [[JAZF1]]. The protein encoded by this gene contains a zinc finger domain in the [[C terminus]] of the coding region. The specific function of this gene has not yet been determined.<ref name="entrez" />
SUZ12, as part of Polycomb Repressive Complex 2 ([[PRC2]]), may be involved with chromatin silencing in conjunction with [[HOTAIR]] ncRNA, using its [[zinc-finger]] domain to bind the RNA molecule.<ref name="Rinn">{{cite journal | vauthors = Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY | title = Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs | journal = Cell | volume = 129 | issue = 7 | pages = 1311–23 | date = June 2007 | pmid = 17604720 | pmc = 2084369 | doi = 10.1016/j.cell.2007.05.022 |author-link11=Howard Y. Chang}}</ref>
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Birve A, Sengupta AK, Beuchle D, Larsson J, Kennison JA, Müller J | title = Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants | journal = Development | volume = 128 | issue = 17 | pages = 3371–9 | date = September 2001 | doi = 10.1242/dev.128.17.3371 | pmid = 11546753 | doi-access = free }}
* {{cite journal | vauthors = Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ | title = Use of chromatin immunoprecipitation to clone novel E2F target promoters | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 6820–32 | date = October 2001 | pmid = 11564866 | pmc = 99859 | doi = 10.1128/MCB.21.20.6820-6832.2001 }}
* {{cite journal | vauthors = Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y | title = Role of histone H3 lysine 27 methylation in Polycomb-group silencing | journal = Science | volume = 298 | issue = 5595 | pages = 1039–43 | date = November 2002 | pmid = 12351676 | doi = 10.1126/science.1076997 | bibcode = 2002Sci...298.1039C | s2cid = 6265267 }}
* {{cite journal | vauthors = Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D | title = Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein | journal = Genes & Development | volume = 16 | issue = 22 | pages = 2893–905 | date = November 2002 | pmid = 12435631 | pmc = 187479 | doi = 10.1101/gad.1035902 }}
* {{cite journal | vauthors = Petek E, Jenne DE, Smolle J, Binder B, Lasinger W, Windpassinger C, Wagner K, Kroisel PM, Kehrer-Sawatzki H | title = Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations | journal = Journal of Medical Genetics | volume = 40 | issue = 7 | pages = 520–5 | date = July 2003 | pmid = 12843325 | pmc = 1735521 | doi = 10.1136/jmg.40.7.520 }}
* {{cite journal | vauthors = Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y | title = mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression | journal = Molecular Cell | volume = 12 | issue = 2 | pages = 475–87 | date = August 2003 | pmid = 14536086 | doi = 10.1016/j.molcel.2003.08.007 | doi-access = free }}
* {{cite journal | vauthors = Huang HY, Ladanyi M, Soslow RA | title = Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity | journal = The American Journal of Surgical Pathology | volume = 28 | issue = 2 | pages = 224–32 | date = February 2004 | pmid = 15043312 | doi = 10.1097/00000478-200402000-00010 | s2cid = 21043514 }}
* {{cite journal | vauthors = Cao R, Zhang Y | title = SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex | journal = Molecular Cell | volume = 15 | issue = 1 | pages = 57–67 | date = July 2004 | pmid = 15225548 | doi = 10.1016/j.molcel.2004.06.020 | doi-access = free }}
* {{cite journal | vauthors = Kehrer-Sawatzki H, Kluwe L, Sandig C, Kohn M, Wimmer K, Krammer U, Peyrl A, Jenne DE, Hansmann I, Mautner VF | title = High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene | journal = American Journal of Human Genetics | volume = 75 | issue = 3 | pages = 410–23 | date = September 2004 | pmid = 15257518 | pmc = 1182020 | doi = 10.1086/423624 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
* {{cite journal | vauthors = Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K | title = Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity | journal = The EMBO Journal | volume = 23 | issue = 20 | pages = 4061–71 | date = October 2004 | pmid = 15385962 | pmc = 524339 | doi = 10.1038/sj.emboj.7600402 }}
* {{cite journal | vauthors = Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC | title = Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3 | journal = Science | volume = 310 | issue = 5746 | pages = 306–10 | date = October 2005 | pmid = 16224021 | doi = 10.1126/science.1118947 | bibcode = 2005Sci...310..306C | s2cid = 23910845 }}
* {{cite journal | vauthors = Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA | title = Control of developmental regulators by Polycomb in human embryonic stem cells | journal = Cell | volume = 125 | issue = 2 | pages = 301–13 | date = April 2006 | pmid = 16630818 | doi = 10.1016/j.cell.2006.02.043 | pmc=3773330}}
* {{cite journal | vauthors = Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K | title = Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro | journal = Biochemical and Biophysical Research Communications | volume = 345 | issue = 3 | pages = 1051–8 | date = July 2006 | pmid = 16712789 | doi = 10.1016/j.bbrc.2006.05.014 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
* {{cite journal | vauthors = Nucci MR, Harburger D, Koontz J, Dal Cin P, Sklar J | title = Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms | journal = The American Journal of Surgical Pathology | volume = 31 | issue = 1 | pages = 65–70 | date = January 2007 | pmid = 17197920 | doi = 10.1097/01.pas.0000213327.86992.d1 | s2cid = 36622314 }}
{{refend}}
== External links ==
* {{FactorBook|SUZ12}}