View source for Sca-1

{{technical|date=February 2015}}
{{for|the neurodegenerative disorder|spinocerebellar ataxia type 1}}
'''Sca-1''' stands for "[[Stem cell]]s [[antigen]]-1" (official gene symbol: Ly6a). It consist of 18-kDa mouse [[glycosyl]] [[phosphatidylinositol]]-anchored [[cell (biology)|cell]] surface [[protein]] (GPI-AP) of the [[LY6]] [[gene family]].<ref>{{Cite journal|last1=Holmes|first1=Christina|last2=Stanford|first2=William L.|date=June 2007|title=Concise Review: Stem Cell Antigen-1: Expression, Function, and Enigma|journal=Stem Cells|language=en|volume=25|issue=6|pages=1339–1347|doi=10.1634/stemcells.2006-0644|pmid=17379763|s2cid=6514438|doi-access=free}}</ref> It is the common [[biological marker]] used to identify hematopoietic stem cell (HSC) along with other markers.
== Application of Sca-1 ==
# Sca-1 has a [[regeneration (biology)|regenerative]] role in [[cardiology|cardiac]] repair: Host cells with specific Sca-1+CD31− markers arise upon [[myocardial infarction]], with evidence of expression of Sca-1 protein.<ref>{{Cite journal|title = The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling.|journal = Stem Cells|doi = 10.1634/stemcells.2005-0386|pmid = 16614004|volume=24 |issue = 7|pages=1779–1788 | last1 = Wang | first1 = X | last2 = Hu | first2 = Q | last3 = Nakamura | first3 = Y | last4 = Lee | first4 = J | last5 = Zhang | first5 = G | last6 = From | first6 = AH | last7 = Zhang | first7 = J|year = 2006| doi-access = free }}</ref>
# Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression.<ref>{{Cite journal|last1=Bradfute|first1=Steven B.|last2=Graubert|first2=Timothy A.|last3=Goodell|first3=Margaret A.|date=July 2005|title=Roles of Sca-1 in hematopoietic stem/progenitor cell function|journal=Experimental Hematology|language=en|volume=33|issue=7|pages=836–843|doi=10.1016/j.exphem.2005.04.001|pmid=15963860|doi-access=free}}</ref>
==References==
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[[Category:Biological techniques and tools]]
[[Category:Genes]]
[[Category:Human proteins]]
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