View source for TRNA:m4X modification enzyme

{{Infobox enzyme
| Name       = TRNA:m4X modification enzyme
| EC_number  = 2.1.1.225
| CAS_number =
| GO_code    =
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'''TRNA:m4X modification enzyme''' ({{EC number|2.1.1.225}}, ''TRM13'', ''Trm13p'', ''tRNA:Xm4 modification enzyme'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase''.<ref>{{cite journal | vauthors = Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM | title = The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4 | journal = RNA | volume = 13 | issue = 3 | pages = 404–13 | date = March 2007 | pmid = 17242307 | pmc = 1800514 | doi = 10.1261/rna.399607 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
: (1) [[S-adenosyl-L-methionine]] + [[cytidine]]<sup>4</sup> in tRNAPro <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + 2'-O-methylcytidine<sup>4</sup> in tRNAPro
: (2) S-adenosyl-L-methionine + cytidine<sup>4</sup> in tRNAGly(GCC) <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + 2'-O-methylcytidine<sup>4</sup> in tRNAGly(GCC)
: (3) S-adenosyl-L-methionine + [[adenosine]]<sup>4</sup> in tRNAHis <math>\rightleftharpoons</math> S-adenosyl-L-homocysteine + 2'-O-methyladenosine<sup>4</sup> in tRNAHis
The enzyme from ''[[Saccharomyces cerevisiae]]'' 2'-O-methylates [[cytidine]]<sup>4</sup> in tRNAPro and tRNAGly(GCC), and [[adenosine]]<sup>4</sup> in tRNAHis.
== References ==
{{reflist}}
== External links ==
* {{MeshName|TRNA:m4X+modification+enzyme}}
{{One carbon transferases}}
{{Enzymes}}
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[[Category:EC 2.1.1]]