View source for UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase
| EC_number  = 2.3.2.10
| CAS_number = 37257-26-4
| GO_code    = 0047206
| image      =
| width      =
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}}
In [[enzymology]], an '''UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase''' ({{EC number|2.3.2.10}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
:L-alanyl-tRNA + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine <math>\rightleftharpoons</math> tRNA + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N<sub>6</sub>-(L-alanyl)-L-lysyl-D- alanyl-D-alanine
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[L-alanyl-tRNA]] and [[UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine]], whereas its 3 [[product (chemistry)|products]] are [[tRNA]], [[UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-]], and [[alanyl-D-alanine]].
This enzyme belongs to the family of [[transferase]]s, specifically the [[aminoacyltransferase]]s.  The [[List of enzymes|systematic name]] of this enzyme class is '''L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-ala nyl-D-alanine N6-alanyltransferase'''. Other names in common use include '''alanyl-transfer ribonucleate-uridine''', '''diphosphoacetylmuramoylpentapeptide transferase''', '''UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase''', '''uridine diphosphoacetylmuramoylpentapeptide lysine''', '''N6-alanyltransferase''', '''L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-''', and '''alanyl-D-alanine 6-N-alanyltransferase'''.  This enzyme participates in [[peptidoglycan biosynthesis]].
==Structural studies==
As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1P4N}}, {{PDB link|1XE4}}, {{PDB link|1XF8}}, and {{PDB link|1XIX}}.
==References==
{{reflist|1}}
* {{cite journal | vauthors = Plapp R, Strominger JL | date = 1970 | title = Biosynthesis of the peptidoglycan of bacterial cell walls. 18 Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens | journal = J. Biol. Chem.  | volume = 245 | pages = 3675&ndash;82  | pmid = 4248527 | issue = 14 | doi = 10.1016/S0021-9258(18)62979-5 | doi-access = free }}
{{Acyltransferases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
[[Category:EC 2.3.2]]
[[Category:Enzymes of known structure]]
{{2.3-enzyme-stub}}