View source for UHMK1

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''U2AF homology motif (UHM) kinase 1''', also known as '''UHMK1''', is a [[protein]] which in humans is encoded by the ''UHMK1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UHMK1 U2AF homology motif (UHM) kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127933}}</ref><ref name="pmid12093740">{{cite journal | vauthors = Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, Nabel EG | title = A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3390–401 |date=July 2002 | pmid = 12093740 | pmc = 126092 | doi = 10.1093/emboj/cdf343 }}</ref>
==Function==
UHMK1 is a [[kinase]] enzyme which [[phosphorylation|phosphorylate]]s the protein [[stathmin]] and has an RNA recognition motif of unknown function.<ref name="pmid12782393">{{cite journal | vauthors = Bièche I, Manceau V, Curmi PA, Laurendeau I, Lachkar S, Leroy K, Vidaud D, Sobel A, Maucuer A | title = Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human | journal = Brain Research. Molecular Brain Research | volume = 114 | issue = 1 | pages = 55–64 |date=May 2003 | pmid = 12782393 | doi = 10.1016/S0169-328X(03)00132-3}}</ref>
==Clinical significance==
UHMK1 is highly expressed in the brain and has been genetically implicated in [[schizophrenia]] in two genetic studies.<ref name = "pmid16978587">{{cite journal   |vauthors=Puri V, McQuillin A, Choudhury K, etal |title=Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene |journal=Biol. Psychiatry |volume=61 |issue= 7 |pages= 873–9 |year= 2007 |pmid= 16978587 |doi= 10.1016/j.biopsych.2006.06.014 |s2cid=26013777 }}</ref><ref name="pmid18414510">{{cite journal | vauthors = Puri V, McQuillin A, Datta S, Choudhury K, Pimm J, Thirumalai S, Krasucki R, Lawrence J, Quested D, Bass N, Crombie C, Fraser G, Walker N, Moorey H, Ray MK, Sule A, Curtis D, St Clair D, Gurling H | title = Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3 | journal = European Journal of Human Genetics | volume = 16 | issue = 10 | pages = 1275–82 |date=October 2008 | pmid = 18414510 | doi = 10.1038/ejhg.2008.76 | doi-access = free }}</ref>   Mice with the gene encoding stathmin [[knockout mouse|knocked out]], so that they do not express this protein in the brain, show abnormal fear responses. This effect could be developed as an [[Animal models of schizophrenia|animal model for schizophrenia]].<ref name="pmid16286011">{{cite journal | vauthors = Shumyatsky GP, Malleret G, Shin RM, Takizawa S, Tully K, Tsvetkov E, Zakharenko SS, Joseph J, Vronskaya S, Yin D, Schubart UK, Kandel ER, Bolshakov VY | title = stathmin, a gene enriched in the amygdala, controls both learned and innate fear | journal = Cell | volume = 123 | issue = 4 | pages = 697–709 |date=November 2005 | pmid = 16286011 | doi = 10.1016/j.cell.2005.08.038 | s2cid = 18332686 | doi-access = free }}</ref>  UHMK1 also phosphorylates the CNS proteins [[myelin basic protein]] (MBP) and [[SYN1|synapsin I]] so that genetic abnormalities in UHMK1 could contribute to the genetic cause of schizophrenia through several different brain pathways. UHMK1 is also implicated in the progression of many cancers such as [[Stomach cancer|gastric]],<ref>{{Cite journal|last1=Feng|first1=Xing|last2=Ma|first2=Dong|last3=Zhao|first3=Jiabao|last4=Song|first4=Yongxi|last5=Zhu|first5=Yuekun|last6=Zhou|first6=Qingxin|last7=Ma|first7=Fei|last8=Liu|first8=Xing|last9=Zhong|first9=Mengya|last10=Liu|first10=Yu|last11=Xiong|first11=Yubo|date=2020-03-02|title=UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism|journal=The EMBO Journal|volume=39|issue=5|pages=e102541|doi=10.15252/embj.2019102541|issn=1460-2075|pmc=7049804|pmid=31975428}}</ref> [[Liver cancer|liver]],<ref>{{Cite journal|last1=Wei|first1=Teng|last2=Weiler|first2=Sofia Maria Elisabeth|last3=Tóth|first3=Marcell|last4=Sticht|first4=Carsten|last5=Lutz|first5=Teresa|last6=Thomann|first6=Stefan|last7=De La Torre|first7=Carolina|last8=Straub|first8=Beate|last9=Merker|first9=Sabine|last10=Ruppert|first10=Thomas|last11=Marquardt|first11=Jens|date=July 2019|title=YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells|url=https://www.nature.com/articles/s41388-019-0801-y|journal=Oncogene|language=en|volume=38|issue=27|pages=5541–5550|doi=10.1038/s41388-019-0801-y|pmid=30936457|s2cid=89616899|issn=1476-5594}}</ref> [[Colorectal cancer|colorectal]],<ref>{{Cite journal|last1=Xu|first1=Xiang-Hao|last2=Song|first2=Wen|last3=Li|first3=Jun-Hua|last4=Huang|first4=Ze-Qi|last5=Liu|first5=Ya-Fang|last6=Bao|first6=Qiang|last7=Shen|first7=Zhi-Wen|date=2021|title=Long Non-coding RNA EBLN3P Regulates UHMK1 Expression by Sponging miR-323a-3p and Promotes Colorectal Cancer Progression|journal=Frontiers in Medicine|volume=8|pages=651600|doi=10.3389/fmed.2021.651600|issn=2296-858X|pmc=8180563|pmid=34109193|doi-access=free}}</ref> [[Cervical cancer|cervical]]<ref>{{Cite journal|last1=Mousavi|first1=Seyedeh Zahra|last2=Poortahmasebi|first2=Vahdat|last3=Mokhtari-Azad|first3=Talat|last4=Shahmahmoodi|first4=Shohreh|last5=Farahmand|first5=Mohammad|last6=Farzanehpour|first6=Mahdieh|last7=Jalilvand|first7=Somayeh|date=December 2020|title=The dysregulation of microarray gene expression in cervical cancer is associated with overexpression of a unique messenger RNA signature|journal=Iranian Journal of Microbiology|volume=12|issue=6|pages=629–635|doi=10.18502/ijm.v12i6.5039|issn=2008-3289|pmc=7884268|pmid=33613919}}</ref> and [[leukemia]].<ref>{{Cite journal|last1=Barbutti|first1=Isabella|last2=Machado-Neto|first2=João Agostinho|last3=Arfelli|first3=Vanessa Cristina|last4=de Melo Campos|first4=Paula|last5=Traina|first5=Fabiola|last6=Saad|first6=Sara Teresinha Olalla|last7=Archangelo|first7=Leticia Fröhlich|date=March 2018|title=The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation|url=https://pubmed.ncbi.nlm.nih.gov/29307747/|journal= Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease|volume=1864|issue=3|pages=959–966|doi=10.1016/j.bbadis.2018.01.004|issn=0925-4439|pmid=29307747}}</ref>
==References==
{{Reflist|2}}
==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Crook MF, Olive M, Xue HH, etal |title=GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression |journal=FASEB J. |volume=22 |issue= 1 |pages= 225–35 |year= 2008 |pmid= 17726090 |doi= 10.1096/fj.07-8573com |doi-access=free |s2cid=20012567 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Bièche I, Manceau V, Curmi PA, etal |title=Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human |journal=Brain Res. Mol. Brain Res. |volume=114 |issue= 1 |pages= 55–64 |year= 2003 |pmid= 12782393 |doi=10.1016/S0169-328X(03)00132-3  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Boehm M, Yoshimoto T, Crook MF, etal |title=A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression |journal=EMBO J. |volume=21 |issue= 13 |pages= 3390–401 |year= 2002 |pmid= 12093740 |doi= 10.1093/emboj/cdf343  | pmc=126092 }}
*{{cite journal   |vauthors=Caldwell BD, Darlington DN, Penzes P, etal |title=The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34646–56 |year= 2000 |pmid= 10574929 |doi=10.1074/jbc.274.49.34646  |doi-access=free }}
*{{cite journal  | vauthors=Maucuer A, Camonis JH, Sobel A |title=Stathmin interaction with a putative kinase and coiled-coil-forming protein domains |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 8 |pages= 3100–4 |year= 1995 |pmid= 7724523 |doi=10.1073/pnas.92.8.3100  | pmc=42112  |bibcode=1995PNAS...92.3100M |doi-access=free }}
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