View source for WBSCR22

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Uncharacterized methyltransferase WBSCR22''' is an [[enzyme]] that in humans is encoded by the ''WBSCR22'' [[gene]].<ref name="pmid12073013">{{cite journal | vauthors = Merla G, Ucla C, Guipponi M, Reymond A | title = Identification of additional transcripts in the Williams-Beuren syndrome critical region | journal = Hum Genet | volume = 110 | issue = 5 | pages = 429–38 |date=Jun 2002 | pmid = 12073013 | doi = 10.1007/s00439-002-0710-x | s2cid = 29964959 }}</ref><ref name="pmid11978965">{{cite journal | vauthors = Doll A, Grzeschik KH | title = Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome | journal = Cytogenet Cell Genet | volume = 95 | issue = 1–2 | pages = 20–7 |date=Apr 2002 | pmid = 11978965 | doi =10.1159/000057012  | s2cid = 21992204 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WBSCR22 Williams Beuren syndrome chromosome region 22| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114049}}</ref>
This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of [[Methyltransferase|methyltransferases]], suggesting that the encoded protein may act on [[DNA methylation]]. This gene is deleted in [[Williams syndrome]], a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.<ref name="entrez">{{cite web | title = Entrez Gene: WBSCR22 Williams Beuren syndrome chromosome region 22| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114049}}</ref>
==References==
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==Further reading==
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*{{cite journal   |vauthors=Stanchi F, Bertocco E, Toppo S, etal |title=Characterization of 16 novel human genes showing high similarity to yeast sequences. |journal=Yeast |volume=18 |issue= 1 |pages= 69–80 |year= 2001 |pmid= 11124703 |doi= 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H |s2cid=21397515 |doi-access=free }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |doi-access= free }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Wan D, Gong Y, Qin W, etal |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101  | pmc=524842 |bibcode=2004PNAS..10115724W |doi-access=free }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 }}
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