View source for ZFYVE26

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Zinc finger, FYVE domain containing 26''' is a [[protein]] that in humans is encoded by the ZFYVE26 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Zinc finger, FYVE domain containing 26 | url = https://www.ncbi.nlm.nih.gov/gene/23503 }}</ref>
== Function ==
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to [[membrane lipids]] through interaction with [[phospholipid]]s in the membrane. Mutations in this gene are associated with [[SPG15 (disease)|autosomal recessive spastic paraplegia-15]].<ref name="entrez"/>
== References ==
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== Further reading ==
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* {{cite journal | vauthors = Elleuch N, Bouslam N, Hanein S, Lossos A, Hamri A, Klebe S, Meiner V, Birouk N, Lerer I, Grid D, Bacq D, Tazir M, Zelenika D, Argov Z, Durr A, Yahyaoui M, Benomar A, Brice A, Stevanin G | title = Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families | journal = Neurogenetics | volume = 8 | issue = 4 | pages = 307–15 | date = Nov 2007 | pmid = 17661097 | doi = 10.1007/s10048-007-0097-x | s2cid = 25209385 }}
* {{cite journal | vauthors = Boukhris A, Stevanin G, Feki I, Denis E, Elleuch N, Miladi MI, Truchetto J, Denora P, Belal S, Mhiri C, Brice A | title = Hereditary spastic paraplegia with mental impairment and thin corpus callosum in Tunisia: SPG11, SPG15, and further genetic heterogeneity | journal = Archives of Neurology | volume = 65 | issue = 3 | pages = 393–402 | date = Mar 2008 | pmid = 18332254 | doi = 10.1001/archneur.65.3.393 | url = http://www.hal.inserm.fr/inserm-00277198 | doi-access = free }}
* {{cite journal | vauthors = Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H | title = A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis | journal = PLOS ONE | volume = 6 | issue = 3 | pages = e17086 | year = 2011 | pmid = 21455500 | pmc = 3063775 | doi = 10.1371/journal.pone.0017086 | bibcode = 2011PLoSO...617086S | doi-access = free }}
* {{cite journal | vauthors = Goizet C, Boukhris A, Maltete D, Guyant-Maréchal L, Truchetto J, Mundwiller E, Hanein S, Jonveaux P, Roelens F, Loureiro J, Godet E, Forlani S, Melki J, Auer-Grumbach M, Fernandez JC, Martin-Hardy P, Sibon I, Sole G, Orignac I, Mhiri C, Coutinho P, Durr A, Brice A, Stevanin G | title = SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum | journal = Neurology | volume = 73 | issue = 14 | pages = 1111–9 | date = Oct 2009 | pmid = 19805727 | doi = 10.1212/WNL.0b013e3181bacf59 | s2cid = 39444163 }}
* {{cite journal | vauthors = Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H | title = PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody | journal = Nature Cell Biology | volume = 12 | issue = 4 | pages = 362–71 | date = Apr 2010 | pmid = 20208530 | doi = 10.1038/ncb2036 | url = https://www.duo.uio.no/bitstream/10852/28044/1/dravhandling-sagona.pdf | hdl = 10852/28044 | s2cid = 2765716 | hdl-access = free }}
* {{cite journal | vauthors = Schüle R, Schlipf N, Synofzik M, Klebe S, Klimpe S, Hehr U, Winner B, Lindig T, Dotzer A, Riess O, Winkler J, Schöls L, Bauer P | title = Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 80 | issue = 12 | pages = 1402–4 | date = Dec 2009 | pmid = 19917823 | doi = 10.1136/jnnp.2008.167528 | s2cid = 23251702 | url = https://hal.archives-ouvertes.fr/hal-00552742 }}
* {{cite journal | vauthors = Murmu RP, Martin E, Rastetter A, Esteves T, Muriel MP, El Hachimi KH, Denora PS, Dauphin A, Fernandez JC, Duyckaerts C, Brice A, Darios F, Stevanin G | title = Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia | journal = Molecular and Cellular Neurosciences | volume = 47 | issue = 3 | pages = 191–202 | date = Jul 2011 | pmid = 21545838 | doi = 10.1016/j.mcn.2011.04.004 | s2cid = 5450391 }}
* {{cite journal | vauthors = Hanein S, Martin E, Boukhris A, Byrne P, Goizet C, Hamri A, Benomar A, Lossos A, Denora P, Fernandez J, Elleuch N, Forlani S, Durr A, Feki I, Hutchinson M, Santorelli FM, Mhiri C, Brice A, Stevanin G | title = Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome | journal = American Journal of Human Genetics | volume = 82 | issue = 4 | pages = 992–1002 | date = Apr 2008 | pmid = 18394578 | pmc = 2427184 | doi = 10.1016/j.ajhg.2008.03.004 }}
* {{cite journal | vauthors = Hughes CA, Byrne PC, Webb S, McMonagle P, Patterson V, Hutchinson M, Parfrey NA | title = SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q | journal = Neurology | volume = 56 | issue = 9 | pages = 1230–3 | date = May 2001 | pmid = 11342696 | doi = 10.1212/wnl.56.9.1230 | s2cid = 31185837 }}
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