View source for Zyxin

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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Zyxin''' is a [[protein]] that in humans is encoded by the ''ZYX'' [[gene]].<ref name="pmid8917469">{{cite journal | vauthors = Zumbrunn J, Trueb B | title = A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts | journal = Eur J Biochem | volume = 241 | issue = 2 | pages = 657–63 | date = January 1997 | pmid = 8917469 | doi = 10.1111/j.1432-1033.1996.00657.x | doi-access = free }}</ref><ref name="pmid8940160">{{cite journal | vauthors = Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle MC | title = Molecular characterization of human zyxin | journal = J Biol Chem | volume = 271 | issue = 49 | pages = 31470–8 | date = January 1997 | pmid = 8940160 | doi = 10.1074/jbc.271.49.31470 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZYX zyxin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791}}</ref>
== Function ==
[[Focal adhesion]]s are actin-rich structures that enable cells to adhere to the [[extracellular matrix]] and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three [[LIM domain]]s in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.<ref name="entrez"/>
== Interactions ==
Zyxin has been shown to [[Protein-protein interaction|interact]] with:
* [[Actinin, alpha 1]]<ref name = pmid10224105>{{cite journal | vauthors = Reinhard M, Zumbrunn J, Jaquemar D, Kuhn M, Walter U, Trueb B | title = An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 13410–8 | date = May 1999 | pmid = 10224105 | doi =  10.1074/jbc.274.19.13410| doi-access = free }}</ref><ref name = pmid11423549>{{cite journal | vauthors = Li B, Trueb B | title = Analysis of the alpha-actinin/zyxin interaction | journal = J. Biol. Chem. | volume = 276 | issue = 36 | pages = 33328–35 | date = September 2001 | pmid = 11423549 | doi = 10.1074/jbc.M100789200 | doi-access =  free}}</ref>
* [[ENAH (gene)|ENAH]],<ref name = pmid12672821>{{cite journal | vauthors = Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T | title = Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase | journal = J. Biol. Chem. | volume = 278 | issue = 24 | pages = 21685–92 | date = June 2003 | pmid = 12672821 | doi = 10.1074/jbc.M301447200 | doi-access = free }}</ref><ref name = pmid10801818>{{cite journal | vauthors = Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM | title = Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins | journal = J. Biol. Chem. | volume = 275 | issue = 29 | pages = 22503–11 | date = July 2000 | pmid = 10801818 | doi = 10.1074/jbc.M001698200 | doi-access = free }}</ref>
* [[LASP1]],<ref name = pmid15004028>{{cite journal | vauthors = Li B, Zhuang L, Trueb B | title = Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1 | journal = J. Biol. Chem. | volume = 279 | issue = 19 | pages = 20401–10 | date = May 2004 | pmid = 15004028 | doi = 10.1074/jbc.M310304200 | doi-access = free }}</ref>
* [[LATS1]],<ref name = pmid10831611>{{cite journal | vauthors = Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, Masuko N, Inagaki M, Hatakeyama K, Saya H | title = Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor | journal = J. Cell Biol. | volume = 149 | issue = 5 | pages = 1073–86 | date = May 2000 | pmid = 10831611 | pmc = 2174824 | doi =  10.1083/jcb.149.5.1073}}</ref>  and
* [[Vasodilator-stimulated phosphoprotein]].<ref name = pmid10801818/><ref name = pmid10882740>{{cite journal | vauthors = Harbeck B, Hüttelmaier S, Schluter K, Jockusch BM, Illenberger S | title = Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin | journal = J. Biol. Chem. | volume = 275 | issue = 40 | pages = 30817–25 | date = October 2000 | pmid = 10882740 | doi = 10.1074/jbc.M005066200 | doi-access = free }}</ref>
== References ==
{{Reflist}}
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Reinhard M, Jouvenal K, Tripier D, Walter U | title = Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein) | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 17 | pages = 7956–60 | year = 1995 | pmid = 7644520 | pmc = 41265 | doi = 10.1073/pnas.92.17.7956 | bibcode = 1995PNAS...92.7956R | doi-access = free }}
* {{cite journal | vauthors = Wang LF, Miao SY, Zong SD, Bai Y, Koide SS | title = Gene encoding a mammalian epididymal protein | journal = Biochem. Mol. Biol. Int. | volume = 34 | issue = 6 | pages = 1131–6 | year = 1995 | pmid = 7696985 }}
* {{cite journal | vauthors = Hobert O, Schilling JW, Beckerle MC, Ullrich A, Jallal B | title = SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin | journal = Oncogene | volume = 12 | issue = 7 | pages = 1577–81 | year = 1996 | pmid = 8622875 }}
* {{cite journal | vauthors = Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S | title = Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells | journal = J. Biol. Chem. | volume = 272 | issue = 47 | pages = 29407–10 | year = 1997 | pmid = 9367993 | doi = 10.1074/jbc.272.47.29407 | doi-access = free }}
* {{cite journal | vauthors = Zumbrunn J, Trueb B | title = Assignment of the ZYX gene for the LIM protein zyxin to human chromosome bands 7q34→q35 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 81 | issue = 3–4 | pages = 283–4 | year = 1998 | pmid = 9730620 | doi = 10.1159/000015047 | s2cid = 46778049 }}
* {{cite journal | vauthors = Yang JX, Miao SY, Wu YW, Zhang Z, Zong SD, Wang LF, Koide SS | title = Gene encoding a human testis Sertoli cell component related to LIM domain protein | journal = Biochem. Mol. Biol. Int. | volume = 46 | issue = 1 | pages = 11–9 | year = 1998 | pmid = 9784834 | doi =  10.1080/15216549800203502| s2cid = 6735908 | doi-access = free }}
* {{cite journal | vauthors = Reinhard M, Zumbrunn J, Jaquemar D, Kuhn M, Walter U, Trueb B | title = An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 13410–8 | year = 1999 | pmid = 10224105 | doi = 10.1074/jbc.274.19.13410 | doi-access = free }}
* {{cite journal | vauthors = Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM | title = Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins | journal = J. Biol. Chem. | volume = 275 | issue = 29 | pages = 22503–11 | year = 2000 | pmid = 10801818 | doi = 10.1074/jbc.M001698200 | doi-access = free }}
* {{cite journal | vauthors = Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, Masuko N, Inagaki M, Hatakeyama K, Saya H | title = Zyxin, a Regulator of Actin Filament Assembly, Targets the Mitotic Apparatus by Interacting with H-Warts/Lats1 Tumor Suppressor | journal = J. Cell Biol. | volume = 149 | issue = 5 | pages = 1073–86 | year = 2000 | pmid = 10831611 | pmc = 2174824 | doi = 10.1083/jcb.149.5.1073 }}
* {{cite journal | vauthors = Smolenski A, Poller W, Walter U, Lohmann SM | title = Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25723–32 | year = 2000 | pmid = 10851246 | doi = 10.1074/jbc.M909632199 | doi-access = free }}
* {{cite journal | vauthors = Harbeck B, Hüttelmaier S, Schluter K, Jockusch BM, Illenberger S | title = Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin | journal = J. Biol. Chem. | volume = 275 | issue = 40 | pages = 30817–25 | year = 2000 | pmid = 10882740 | doi = 10.1074/jbc.M005066200 | doi-access = free }}
* {{cite journal | vauthors = Schenker T, Trueb B | title = BSPRY, a novel protein of the Ro-Ret family | journal = Biochim. Biophys. Acta | volume = 1493 | issue = 1–2 | pages = 255–8 | year = 2000 | pmid = 10978534 | doi = 10.1016/s0167-4781(00)00167-6 }}
* {{cite journal | vauthors = Li B, Trueb B | title = Analysis of the alpha-actinin/zyxin interaction | journal = J. Biol. Chem. | volume = 276 | issue = 36 | pages = 33328–35 | year = 2001 | pmid = 11423549 | doi = 10.1074/jbc.M100789200 | doi-access =  free}}
* {{cite journal | vauthors = Degenhardt YY, Silverstein S | title = Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human Papillomavirus Type 6 Results in Its Nuclear Translocation | journal = J. Virol. | volume = 75 | issue = 23 | pages = 11791–802 | year = 2001 | pmid = 11689660 | pmc = 114765 | doi = 10.1128/JVI.75.23.11791-11802.2001 }}
* {{cite journal | vauthors = Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC | title = Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers | journal = J. Biol. Chem. | volume = 277 | issue = 11 | pages = 9580–9 | year = 2002 | pmid = 11782456 | doi = 10.1074/jbc.M106922200 | doi-access = free }}
* {{cite journal | vauthors = van der Gaag EJ, Leccia MT, Dekker SK, Jalbert NL, Amodeo DM, Byers HR | title = Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes | journal = J. Invest. Dermatol. | volume = 118 | issue = 2 | pages = 246–54 | year = 2002 | pmid = 11841540 | doi = 10.1046/j.0022-202x.2001.01657.x | doi-access = free }}
{{Refend}}
== External links ==
* [https://web.archive.org/web/20110722012353/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00002107 Zyxin] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] {{Webarchive|url=https://web.archive.org/web/20141211173306/http://www.cellmigration.org/index.shtml |date=2014-12-11 }}
[[Category:Cytoskeleton]]