PIK3R2
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An Error has occurred retrieving Wikidata item for infobox Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.[1][2] A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.[3]
Interactions
PIK3R2 has been shown to interact with:
- CRKL[4]
- Cbl gene,[5][6]
- Epidermal growth factor,[7]
- FYN,[7]
- HER2/neu,[7]
- Macrophage colony-stimulating factor,[7] and
- PIK3CD.[8]
Clinical relevance
PIK3R2 mutations were recently shown to be associated with polymicrogyria.[9]
References
- ↑ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, et al. (April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789–793. PMID 1314371.
- ↑ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)".
- ↑ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.
- ↑ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574.
- ↑ Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.
- ↑ Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144.
- ↑ 7.0 7.1 7.2 7.3 Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
- ↑ Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
- ↑ Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, et al. (December 2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". The Lancet. Neurology. 14 (12): 1182–1195. doi:10.1016/S1474-4422(15)00278-1. PMC 4672724. PMID 26520804.
Further reading
- Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (November 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–682. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
- Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
- Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (November 1990). "Purification and characterization of phosphoinositide 3-kinase from rat liver". The Journal of Biological Chemistry. 265 (32): 19704–19711. doi:10.1016/S0021-9258(17)45429-9. PMID 2174051.
- Truitt KE, Hicks CM, Imboden JB (March 1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells". The Journal of Experimental Medicine. 179 (3): 1071–1076. doi:10.1084/jem.179.3.1071. PMC 2191424. PMID 7509360.
- Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". Biochemistry. 34 (17): 5971–5979. doi:10.1021/bi00017a026. PMID 7537096.
- Craparo A, O'Neill TJ, Gustafson TA (June 1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor". The Journal of Biological Chemistry. 270 (26): 15639–15643. doi:10.1074/jbc.270.26.15639. PMID 7541045.
- He W, O'Neill TJ, Gustafson TA (October 1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains". The Journal of Biological Chemistry. 270 (40): 23258–23262. doi:10.1074/jbc.270.40.23258. PMID 7559478.
- Kapeller R, Toker A, Cantley LC, Carpenter CL (October 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry. 270 (43): 25985–25991. doi:10.1074/jbc.270.43.25985. PMID 7592789.
- Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144.
- Pandey A, Lazar DF, Saltiel AR, Dixit VM (December 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of Biological Chemistry. 269 (48): 30154–30157. doi:10.1016/S0021-9258(18)43790-8. PMID 7982920.
- August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology. 6 (5): 769–774. doi:10.1093/intimm/6.5.769. PMID 8080844.
- Fukazawa T, Miyake S, Band V, Band H (June 1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins". The Journal of Biological Chemistry. 271 (24): 14554–14559. doi:10.1074/jbc.271.24.14554. PMID 8662998.
- Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (September 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". The Journal of Biological Chemistry. 271 (38): 22961–22964. doi:10.1074/jbc.271.38.22961. PMID 8798481.
- Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574.
- Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
- Briand G, Barbeau B, Tremblay M (February 1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase". Virology. 228 (2): 171–179. doi:10.1006/viro.1996.8399. PMID 9123823.
- Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, et al. (June 1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site". Oncogene. 14 (22): 2619–2631. doi:10.1038/sj.onc.1201123. PMID 9178760.
- Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, et al. (July 1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle". The Journal of Biological Chemistry. 272 (30): 19000–19007. doi:10.1074/jbc.272.30.19000. PMID 9228082.
- Mazerolles F, Barbat C, Fischer A (September 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology. 27 (9): 2457–2465. doi:10.1002/eji.1830270946. PMID 9341793. S2CID 33397908.