Deltex e3 ubiquitin ligase 3
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Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene.[1] It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c.[2] DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.[2]
Function
DTX3 functions as an E3 ubiquitin ligase.[3] Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.[2]
References
- ↑ "Entrez Gene: Deltex E3 ubiquitin ligase 3". Retrieved 2016-09-26.
- ↑ 2.0 2.1 2.2 Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi:10.3390/cells12131680. ISSN 2073-4409. PMC 10340142. PMID 37443713.
- ↑ Takeyama, Kunihiko; Aguiar, Ricardo C. T.; Gu, Liqun; He, Chunyan; Freeman, Gordon J.; Kutok, Jeffery L.; Aster, Jon C.; Shipp, Margaret A. (2003-06-13). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–21937. doi:10.1074/jbc.M301157200. ISSN 0021-9258. PMID 12670957.
Further reading
- Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
