Neurotensin receptor 2
An Error has occurred retrieving Wikidata item for infobox Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]
Function
The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.[3] Binding and pharmacological studies demonstrate that this receptor binds Neurotensin (NT) as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a neuromodulator of dopamine and has hypothermic and analgesic properties in the brain and some peripheral organ function as well.[4] NTS2 is found mostly in the brain through Northern-blot analysis.[4]Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.[4]
See also
References
- ↑ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, et al. (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters. 386 (2–3): 91–94. doi:10.1016/0014-5793(96)00397-3. PMID 8647296. S2CID 5802578.
- ↑ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, et al. (November 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology. 360 (2–3): 265–272. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
- ↑ 3.0 3.1 "NTSR2 neurotensin receptor 2". Entrez Gene. U.S. National Library of Medicine.
- ↑ 4.0 4.1 4.2 Vincent JP, Mazella J, Kitabgi P (July 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–309. doi:10.1016/s0165-6147(99)01357-7. PMID 10390649.
Further reading
- Vincent JP, Mazella J, Kitabgi P (July 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–309. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
- Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP (September 1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". The Journal of Neuroscience. 16 (18): 5613–5620. doi:10.1523/jneurosci.16-18-05613.1996. PMC 6578974. PMID 8795617.
- Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, et al. (September 2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". The Journal of Investigative Dermatology. 117 (3): 687–693. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
- Martin S, Vincent JP, Mazella J (January 2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". Journal of Cell Science. 115 (Pt 1): 165–173. doi:10.1242/jcs.115.1.165. PMID 11801734.
- Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, et al. (June 2002). "Expression of neurotensin receptors in human corneal keratocytes". Investigative Ophthalmology & Visual Science. 43 (6): 1765–1771. PMID 12036977.
- Leyton J, Garcia-Marin L, Jensen RT, Moody TW (May 2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". European Journal of Pharmacology. 442 (3): 179–186. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.
- Somaï S, Gompel A, Rostène W, Forgez P (July 2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications. 295 (2): 482–488. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
- Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW (December 2004). "Common structural basis for constitutive activity of the ghrelin receptor family". The Journal of Biological Chemistry. 279 (51): 53806–53817. doi:10.1074/jbc.M407676200. PMID 15383539.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links
- "Neurotensin Receptors: NTS2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
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