PIR (gene)
An Error has occurred retrieving Wikidata item for infobox Pirin is a protein that in humans is encoded by the PIR gene.[1][2] This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[2]
Interactions
PIR (gene) has been shown to interact with BCL3.[3]
Pirin in Bacteria
The pir gene is conserved in both bacteria and eukaryotes. In Pseudomonas stutzeri this protein exhibited quercetinase activity.[4] In Streptomyces ambofaciens, a strain known to produce the antibiotic spiramycin, the pirA gene regulates the AcdB enzyme that catalyzes one of the first steps of beta-oxidation.[5] Loss of the pirA gene causes a metabolic imbalance that reduces the amount of antibiotic produced.[5]
References
- ↑ Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
- ↑ 2.0 2.1 "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
- ↑ Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.
- ↑ Widiatningrum, Talitha; Maeda, Sorato; Kataoka, Kunishige; Sakurai, Takeshi (2015-08-07). "A pirin-like protein from Pseudomonas stutzeri and its quercetinase activity". Biochemistry and Biophysics Reports. 3: 144–149. doi:10.1016/j.bbrep.2015.08.001. ISSN 2405-5808. PMC 5668851. PMID 29124178.
- ↑ 5.0 5.1 Talà, Adelfia; Damiano, Fabrizio; Gallo, Giuseppe; Pinatel, Eva; Calcagnile, Matteo; Testini, Mariangela; Fico, Daniela; Rizzo, Daniela; Sutera, Alberto; Renzone, Giovanni; Scaloni, Andrea; De Bellis, Gianluca; Siculella, Luisa; De Benedetto, Giuseppe Egidio; Puglia, Anna Maria (July 2018). "Pirin: A novel redox-sensitive modulator of primary and secondary metabolism in Streptomyces". Metabolic Engineering. 48: 254–268. doi:10.1016/j.ymben.2018.06.008. ISSN 1096-7184. PMID 29944936.
Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity". J. Biol. Chem. 280 (31): 28675–82. doi:10.1074/jbc.M501034200. PMID 15951572.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor". J. Biol. Chem. 279 (2): 1491–8. doi:10.1074/jbc.M310022200. PMID 14573596.
- Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin". Acta Crystallogr. D. 59 (Pt 8): 1496–8. doi:10.1107/S0907444903012289. PMID 12876364.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
