Cytosol nonspecific dipeptidase
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| Cytosol nonspecific dipeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.13.18 | ||||||||
| CAS no. | 9025-31-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.[1][2][3] This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor.[4] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".[5] A similiar pathway conjugates amino acids to Beta-hydroxybutyric acid.[6]
See also
- N-lactoyl-phenylalanine, a chemical compound produced by this enzyme
References
- ↑ Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, et al. (February 2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". The Journal of Biological Chemistry. 278 (8): 6521–6531. doi:10.1074/jbc.M209764200. PMID 12473676.
- ↑ "Entrez Gene: CNDP2 carnosine dipeptidase 2".
- ↑ Bauer K (1998). "Cytosol non-specific dipeptidase". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 1520–1522.
- ↑ "UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens".
- ↑ Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. (May 11, 2015). "N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids". Proceedings of the National Academy of Sciences of the USA. 112 (21): 6601–6606. Bibcode:2015PNAS..112.6601J. doi:10.1073/pnas.1424638112. PMC 4450436. PMID 25964343.
- ↑ Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, et al. (2024). "A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites". Cell. doi:10.1016/j.cell.2024.10.032. PMID 39536746.
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External links
- Cytosol+non-specific+dipeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
