THEMIS (protein)

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An Error has occurred retrieving Wikidata item for infobox THEMIS is a protein encoded by the eponymous THEMIS gene.[1][2][3]

Function

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[4] Changes in THEMIS gene expression due to the rs138300818 variant promote the development of early-onset type 1 diabetes.[5]

Etymology

THEMIS is an acronym for thymocyte-expressed molecule involved in selection. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.[6]

References

  1. Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, et al. (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nature Immunology. 10 (8): 848–856. doi:10.1038/ni.1766. PMC 2757056. PMID 19597499.
  2. Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, et al. (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nature Immunology. 10 (8): 840–847. doi:10.1038/ni.1768. PMC 2848698. PMID 19597498.
  3. Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, et al. (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nature Immunology. 10 (8): 831–839. doi:10.1038/ni.1769. PMC 2908989. PMID 19597497.
  4. "Entrez Gene: thymocyte selection associated".
  5. Sandholm N, Rubio García A, Pekalski ML, Inshaw JR, Cutler AJ, Todd JA (August 2022). "Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants". Scientific Reports. 12 (1): 14137. Bibcode:2022NatSR..1214137S. doi:10.1038/s41598-022-18296-4. PMC 9391468. PMID 35986039.
  6. Zielinska E (2009-11-01). "Six degrees of science". The Scientist. Archived from the original on 2009-11-06. Retrieved 2009-11-03.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.