The 1910 edition was contested by 14 clubs, 9 within Buenos Aires Province and 5 from Liga Rosarina de Football. Estudiantes entered directly in quarterfinal, where the squad defeated Argentino de Rosario 1–0, then eliminating Newell's Old Boys (4–3 in playoff after a 4–4 draw), allowing them to play the final.[2]
On the other hand, Gimnasia y Esgrima eliminated River Plate after beating them 3–0, then eliminating Quilmes at home, and finally defeating Provincial in Rosario to earn a place in the final. The three games were won by the same score: 3–0.[3]
↑ 1.01.1As there were several fields in the barrio of Palermo by those times, it is unclear if the match was held in Gimnasia y Esgrima ("Sede Maldonado"), Estudiantes BA (Av. del Libertador y Oro), Porteño (Av. del Libertador y Godoy Cruz), or Sociedad Sportiva (Av. del Libertador y Dorrego).[1]