CLDN19
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An Error has occurred retrieving Wikidata item for infobox Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.[1] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.[2][3] Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM][1]
References
- ↑ 1.0 1.1 "Entrez Gene: CLDN19 claudin 19".
- ↑ Naeem M, Hussain S, Akhtar N (2011). "Mutation in the tight-junction gene claudin 19 (CLDN19) and familial hypomagnesemia, hypercalciuria, nephrocalcinosis (FHHNC) and severe ocular disease". American Journal of Nephrology. 34 (3): 241–248. doi:10.1159/000330854. PMID 21791920.
- ↑ Konrad M, Schaller A, Seelow D, Pandey AV, Waldegger S, Lesslauer A, et al. (November 2006). "Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement". American Journal of Human Genetics. 79 (5): 949–957. doi:10.1086/508617. PMC 1698561. PMID 17033971.
External links
- Human CLDN19 genome location and CLDN19 gene details page in the UCSC Genome Browser.
Further reading
- Kniesel U, Wolburg H (February 2000). "Tight junctions of the blood-brain barrier". Cellular and Molecular Neurobiology. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
- Heiskala M, Peterson PA, Yang Y (February 2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–98. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
- Tsukita S, Furuse M, Itoh M (April 2001). "Multifunctional strands in tight junctions". Nature Reviews. Molecular Cell Biology. 2 (4): 285–293. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
- Tsukita S, Furuse M (October 2002). "Claudin-based barrier in simple and stratified cellular sheets". Current Opinion in Cell Biology. 14 (5): 531–536. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
- González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (January 2003). "Tight junction proteins". Progress in Biophysics and Molecular Biology. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
- Lee NP, Tong MK, Leung PP, Chan VW, Leung S, Tam PC, et al. (February 2006). "Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease". FEBS Letters. 580 (3): 923–931. Bibcode:2006FEBSL.580..923L. doi:10.1016/j.febslet.2006.01.019. PMID 16427635. S2CID 21297265.
- Konrad M, Schaller A, Seelow D, Pandey AV, Waldegger S, Lesslauer A, et al. (November 2006). "Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement". American Journal of Human Genetics. 79 (5): 949–957. doi:10.1086/508617. PMC 1698561. PMID 17033971.
- Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, et al. (February 2016). "Systems Proteomics View of the Endogenous Human Claudin Protein Family". Journal of Proteome Research. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.
