Chromosome 6 open reading frame 203
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Chromosome 6 open reading frame 203 is a protein that in humans is encoded by the C6orf203 gene. [1] C6orf203 protein is reported to be localised to the mitochondria of eukaryotes and possess an evolutionarily conserved RNA-binding domain.[2][3] One study propose C6orf203 to associate with mitochondrial RNA polymerase (POLRMT) and increase mitochondrial transcription to protect the cell from mitochondrial RNA loss during stress.[3] However, another study propose C6orf203 to associate with the mitoribosomal large subunit and regulate mitochondrial translation.[2]
References
- ↑ "Entrez Gene: Chromosome 6 open reading frame 203". Retrieved 2018-05-11.
- ↑ 2.0 2.1 Gopalakrishna S, Pearce SF, Dinan AM, Schober FA, Cipullo M, Spåhr H, et al. (August 2019). "C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis". Nucleic Acids Research. 47 (17): 9386–9399. doi:10.1093/nar/gkz684. PMC 6755124. PMID 31396629.
- ↑ 3.0 3.1 Kotrys AV, Cysewski D, Czarnomska SD, Pietras Z, Borowski LS, Dziembowski A, Szczesny RJ (June 2019). "Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria". Nucleic Acids Research. 47 (14): 7502–7517. doi:10.1093/nar/gkz542. PMC 6698753. PMID 31226201.
Further reading
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