Citiolone

Citiolone
	File:Citiolone.png
Clinical data
ATC code	A05BA04 (WHO) ;
Identifiers
	IUPAC name (RS)-N-(2-Oxothiolan-3-yl)acetamide;
CAS Number	1195-16-0 check;
PubChem CID	14520;
ChemSpider	13864 check;
UNII	70JKL15MUH;
KEGG	D07105 check;
ChEMBL	ChEMBL2104457 ☒;
Chemical and physical data
Formula	C6H9NO2S
Molar mass	159.20 g·mol−1
	InChI InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8) check; Key:NRFJZTXWLKPZAV-UHFFFAOYSA-N check;
	☒check (what is this?) (verify)

Citiolone is a drug used in liver therapy. It is a derivative of the amino acid cysteine.^[1] Citilone has also been studied with regards to hypothermia due to it being a hydroxyl free radical scavenger. The drug has been shown to protect hamster cells subjected to temperature conditions of 8-25 °C.^[2]

References

↑ de Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T (1997). "Recurrent fixed drug eruption caused by citiolone". Journal of Investigational Allergology & Clinical Immunology. 7 (3): 193–194. PMID 9252880.
↑ Kruuv J, Glofcheski DJ (June 1993). "Further evidence for two modes of hypothermia damage". Cryobiology. 30 (3): 313–321. doi:10.1006/cryo.1993.1030. PMID 8370318.

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[1] Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T (1997). "Recurrent fixed drug eruption caused by citiolone". Journal of Investigational Allergology & Clinical Immunology. 7 (3): 193–194. PMID 9252880.

[2] Kruuv J, Glofcheski DJ (June 1993). "Further evidence for two modes of hypothermia damage". Cryobiology. 30 (3): 313–321. doi:10.1006/cryo.1993.1030. PMID 8370318.

[1]

[2]

v t e Bile and liver therapy (A05)
Bile therapy	bile acid Chenodeoxycholic acid Cholic acid Obeticholic acid Ursodeoxycholic acid Ursodoxicoltaurine Cyclobutyrol Elafibranor Hymecromone Maralixibat chloride Menbutone Nicotinyl methylamide Odevixibat Piprozolin Seladelpar
Liver therapy	Arginine glutamate Citiolone Epomediol Glycyrrhizin Metadoxine Methionine Ornithine oxoglutarate Phospholipids Silymarin Tidiacic arginine

Citiolone

References

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Clinical data
File:Citiolone.png
ATC code	A05BA04 (WHO)
Identifiers
IUPAC name (RS)-N-(2-Oxothiolan-3-yl)acetamide
CAS Number	1195-16-0^checkY
PubChem CID	14520
ChemSpider	13864^checkY
UNII	70JKL15MUH
KEGG	D07105^checkY
ChEMBL	ChEMBL2104457^☒N
Chemical and physical data
Formula	C₆H₉NO₂S
Molar mass	159.20 g·mol⁻¹
InChI InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8)^checkY Key:NRFJZTXWLKPZAV-UHFFFAOYSA-N^checkY
^☒NcheckY (what is this?) (verify)