DHRSX
From The Right Wiki
Jump to navigationJump to search
An Error has occurred retrieving Wikidata item for infobox Dehydrogenase/reductase (SDR family) X-linked also known as DHRSX is an enzyme which in humans is encoded by the pseudoautosomal DHRSX gene.[1] DHRSX is a member of the short-chain dehydrogenase family of oxidoreductase enzymes.[2] DHRSX is required for two steps in the biosynthesis of dolichol: i) the NAD+-dependent conversion of polyprenol to its aldehyde analogue, polyprenal; ii) the NADPH-dependent reduction of dolichal to dolichol.[3] Dolichol is a long polyisoprenoid lipid required as the carrier of mono- and oligosaccharides in the processes of N-glycosylation, C-/O-mannosylation and the formation of glycosylphosphatidylinositol (GPI) anchors.
References
- ↑ Gianfrancesco F, Sanges R, Esposito T, Tempesta S, Rao E, Rappold G, et al. (December 2001). "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution". Genome Research. 11 (12): 2095–2100. doi:10.1101/gr.197001. PMC 311231. PMID 11731500.
- ↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
- ↑ Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, et al. (July 2024). "A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis". Cell. 187 (14): 3585–3601.e22. doi:10.1016/j.cell.2024.04.041. PMC 11250103. PMID 38821050.
Further reading
- Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, et al. (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, et al. (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
