DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene .[ 5] [ 6] [ 7] fusion protein of DNAJB1 and PRKACA drives fibrolamellar hepatocellular carcinoma , a type of rare liver cancer.[ 8]
Interactions DNAJB1 has been shown to interact with:
References
↑ Jump up to: 1.01.1 1.2 GRCh38: Ensembl release 89: ENSG00000132002 – Ensembl , May 2017↑ Jump up to: 2.02.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000005483 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Hata M, Okumura K, Seto M, Ohtsuka K (December 1996). "Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2". Genomics . 38 (3): 446– 449. doi :10.1006/geno.1996.0653 . PMID 8975727 . ↑ Ohtsuka K (November 1993). "Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ". Biochemical and Biophysical Research Communications . 197 (1): 235– 240. doi :10.1006/bbrc.1993.2466 . PMID 8250930 . ↑ "Entrez Gene: DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1" .↑ Neumayer C, Ng D, Jiang CS, Qureshi A, Lalazar G, Vaughan R, et al. (January 2023). "Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA" . Clinical Cancer Research . 29 (1): 271– 278. doi :10.1158/1078-0432.CCR-22-1851 . PMC 9811160 PMID 36302174 . ↑ Oh WK, Song J (August 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation" . Molecules and Cells . 16 (1): 84– 91. doi :10.1016/S1016-8478(23)13770-8 PMID 14503850 . ↑ Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, et al. (June 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions" . Molecular and Cellular Biology . 19 (6): 4535– 4545. doi :10.1128/mcb.19.6.4535 . PMC 104411 PMID 10330192 .
Further reading
Hattori H, Liu YC, Tohnai I, Ueda M, Kaneda T, Kobayashi T, et al. (February 1992). "Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells" . Cell Structure and Function . 17 (1): 77– 86. doi :10.1247/csf.17.77 PMID 1586970 . S2CID 21909960 . Raabe T, Manley JL (December 1991). "A human homologue of the Escherichia coli DnaJ heat-shock protein" . Nucleic Acids Research . 19 (23): 6645. doi :10.1093/nar/19.23.6645 . PMC 329243 PMID 1754405 . Freeman BC, Morimoto RI (June 1996). "The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding" . The EMBO Journal . 15 (12): 2969– 2979. doi :10.1002/j.1460-2075.1996.tb00660.x . PMC 450238 PMID 8670798 . Qian YQ, Patel D, Hartl FU, McColl DJ (July 1996). "Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain". Journal of Molecular Biology . 260 (2): 224– 235. doi :10.1006/jmbi.1996.0394 . PMID 8764402 . Shi Y, Mosser DD, Morimoto RI (March 1998). "Molecular chaperones as HSF1-specific transcriptional repressors" . Genes & Development . 12 (5): 654– 666. doi :10.1101/gad.12.5.654 . PMC 316571 PMID 9499401 . Hata M, Ohtsuka K (April 1998). "Characterization of HSE sequences in human Hsp40 gene: structural and promoter analysis". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1397 (1): 43– 55. doi :10.1016/S0167-4781(97)00208-X . PMID 9545528 . Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R (August 1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1" . Cell . 94 (4): 471– 480. doi :10.1016/S0092-8674(00)81588-3 PMID 9727490 . S2CID 9234420 . Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG (February 1999). "The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity" . The Journal of Biological Chemistry . 274 (6): 3797– 3803. doi :10.1074/jbc.274.6.3797 PMID 9920933 . Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, et al. (June 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions" . Molecular and Cellular Biology . 19 (6): 4535– 4545. doi :10.1128/mcb.19.6.4535 . PMC 104411 PMID 10330192 . Michels AA, Kanon B, Bensaude O, Kampinga HH (December 1999). "Heat shock protein (Hsp) 40 mutants inhibit Hsp70 in mammalian cells" . The Journal of Biological Chemistry . 274 (51): 36757– 36763. doi :10.1074/jbc.274.51.36757 PMID 10593983 . Terada K, Mori M (August 2000). "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70" . The Journal of Biological Chemistry . 275 (32): 24728– 24734. doi :10.1074/jbc.M002021200 PMID 10816573 . Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature" . Cell Stress & Chaperones . 5 (2): 98– 112. doi :10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-11-02). PMC 312896 PMID 11147971 . {{cite journal }}: CS1 maint: DOI inactive as of November 2024 (link )Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". American Journal of Physiology. Renal Physiology . 281 (2): F326 – F336 . doi :10.1152/ajprenal.2001.281.2.F326 . PMID 11457725 . S2CID 15719851 . Pang Q, Keeble W, Christianson TA, Faulkner GR, Bagby GC (August 2001). "FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity" . The EMBO Journal . 20 (16): 4478– 4489. doi :10.1093/emboj/20.16.4478 . PMC 125562 PMID 11500375 . Hernández MP, Chadli A, Toft DO (April 2002). "HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor" . The Journal of Biological Chemistry . 277 (14): 11873– 11881. doi :10.1074/jbc.M111445200 PMID 11809754 . Anwar A, Siegel D, Kepa JK, Ross D (April 2002). "Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1" . The Journal of Biological Chemistry . 277 (16): 14060– 14067. doi :10.1074/jbc.M111576200 PMID 11821413 . Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research . 289 (2): 211– 221. doi :10.1016/S0014-4827(03)00261-1 . PMID 14499622 . Honeyman JN, Simon EP, Robine N, Chiaroni-Clarke R, Darcy DG, Lim II, et al. (February 2014). "Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma" . Science . 343 (6174): 1010– 1014. Bibcode :2014Sci...343.1010H . doi :10.1126/science.1249484 . PMC 4286414 PMID 24578576 .
