FMNL2
An Error has occurred retrieving Wikidata item for infobox Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[1][2]
Expression
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[1] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[3]) is regulated through autoinhibition, and may become activated through Rho proteins.[4] The FMNL2 gene is expressed in multiple human tissues.[5]
Function
Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[1]
Clinical significance
FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[6] Clinical studies showed that single nucleotide polymorphisms in the FMNL2 gene are associated with cardio and cerebrovascular risk factors and Alzheimer's disease[7] FMNL2 links vascular disease to increased risk of Alzheimer's disease by regulating the interaction between astrocytes and blood vessels in healthy and Alzheimer's disease brains.[8]
See also
References
- ↑ 1.0 1.1 1.2 "Entrez Gene: FMNL2 formin-like 2".
- ↑ Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
- ↑ "formin-like protein 2 [Homo sapiens]" (NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R (April 2010). "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC". Oncogene. 29 (16): 2441–8. doi:10.1038/onc.2009.515. PMID 20101212.
- ↑ Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O (2010). "Characterization of Diaphanous-related formin FMNL2 in human tissues". BMC Cell Biol. 11: 55. doi:10.1186/1471-2121-11-55. PMC 2912821. PMID 20633255.
- ↑ Zhu XL, Liang L, Ding YQ (November 2008). "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer". Int J Colorectal Dis. 23 (11): 1041–7. doi:10.1007/s00384-008-0520-2. PMID 18665374. S2CID 22119273.
- ↑ Lee AJ, Raghavan NS, Bhattarai P, Siddiqui T, Sariya S, Reyes-Dumeyer D, et al. (May 2022). "FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease". Acta Neuropathologica. 144 (1): 59–79. doi:10.1007/s00401-022-02431-6. PMC 9217776. PMID 35608697.
- ↑ "Missing Link Between Alzheimer's and Vascular Disease Found?". 24 May 2022.
