HEPACAM2

An Error has occurred retrieving Wikidata item for infobox HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene.

Function

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis. Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.