HLA-A66

From The Right Wiki
Jump to navigationJump to search
HLA-A66
(MHC Class I, A cell surface antigen)
File:Illustration HLA-A.png
HLA-A66
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*66--, β2-microglobulin
Older namesA10
Subtypes
Subtype
allele
Available structures
A66.1 *6601
A66.2 *6602
{{{cNick3}}} *66{{{cAllele3}}}
{{{cNick4}}} *66{{{cAllele4}}}
Rare alleles
Subtype
allele
Available structures
A66.3 *6603
{{{rnick2}}} *66{{{rallele2}}}
{{{rnick3}}} *66{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α66 subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus.[1] A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

Further information: History and naming of human leukocyte antigens

A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].

Serotype

A66 recognition of some HLA A*66 gene products[3]
A*66 A66 A10 A26 A34 Sample
allele % % % % size (N)
*6601 20 10 61 8 799
*6602 38 10 4 27 205
*6603 32 7 7 18 28

A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.

A*6601 Frequencies

HLA A*6601 frequencies
freq
ref. Population (%)
[4] Cameroon Sawa 7.7
[4] Kenya Luo 6.8
[4] Cameroon Sawa 7.7
[4] Cameroon Bakola Pygmy 5.8
[4] Cameroon Baka Pygmy 5.0
[4] Kenya Nandi 5.0
[4] Zimbabwe Harare Shona 0.2
[4] Cameroon Baka Pygmy 5.0
[4] Cameroon Beti 4.6
[4] Cameroon Bamileke 4.5
[4] India West Bhils 4.0
[4] Zimbabwe Harere Shona 3.8
[4] Uganda Kampala 3.8
[4] India Mumbai Marathas 2.5
[4] Cape Verde Northwestern 2.5
[4] Czech republic 2.4
[4] Morocco Nador Metalsa 2.1
[4] Central Portugal 2.0
[4] India West Parsis 2.0
[4] South African Natal Zulu 2.0
[4] Kenya 1.7
[4] Tunisia Tunis 1.7
[4] Guinea Bissau 1.5
[4] Georgia Tbilisi 1.4
[4] Zambia Lusaka 1.2
[4] Italy Bergamo 1.1
[4] Pakistan Karachi Parsi 1.1
[4] Oman 0.8
[4] Sudanese 0.8
[4] Belgium 0.5
[4] Southeast France 0.4
[4] Mongolia Buriat 0.4
[4] Wales 0.2
HLA A*6602 frequencies
freq
ref. Population (%)
[4] South African Natal Zulu 1.5
[4] Cameroon Yaounde 1.1
[4] Cameroon Bamileke 0.6
[4] Senegal Niokholo Mandenka 0.5
[4] Kenya Nandi 0.4
[4] Zimbabwe Harare Shona 0.2
[4] Wales 0.03
HLA A*6603 frequencies
freq
ref. Population (%)
[4] Cameroon Pygmy Baka 10.0
[4] Cameroon Bakola Pygmy 9.0
[4] Cameroon Sawa 7.7
[4] CAR Mbenzele Pygmy 2.8
[4] Zimbabwe Harare Shona 0.2

References

  1. ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ↑ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
  3. ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 4.39 4.40 4.41 4.42 4.43 4.44 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
Retrieved from "https://rightwiki.org/index.php?title=HLA-A66&oldid=5090381"