HuD (protein)

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An Error has occurred retrieving Wikidata item for infobox HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.[1][2] The HuD/ELAVL4 protein is an RNA-binding protein.[3] HuD contains three RRM protein domains, enabling RNA binding.[4] HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[5][6]

Interactions

HuD (protein) has been shown to interact with NXF1.[7]

References

  1. Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet. 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755.
  2. "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)".
  3. Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278. S2CID 26037558.
  4. Lukong KE, Chang Kw, Khandjian EW, Richard S (2008-08-01). "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416–425. doi:10.1016/j.tig.2008.05.004. ISSN 0168-9525. PMID 18597886.
  5. Nora Perrone-Bizzozero, Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res. 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657.
  6. Federico Bolognani, Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res. 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436. S2CID 27076039.
  7. Saito K, Fujiwara Toshinobu, Katahira Jun, Inoue Kunio, Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. 321 (2). United States: 291–7. doi:10.1016/j.bbrc.2004.06.140. ISSN 0006-291X. PMID 15358174.

Further reading