LG-2527 is a nonsteroidal progestin which was under development by Ligand Pharmaceuticals and Wyeth for the treatment of menopausal symptoms and breast cancer, but was never marketed.[1] It reached the preclinical stage of development prior to the discontinuation of its development in early 2001.[1]
References
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| PRTooltip Progesterone receptor | | Agonists |
- Progesterone derivatives: 3β-Dihydroprogesterone
- 5α-Dihydroprogesterone
- 6α-Methylprogesterone
- 9α-Bromo-11-ketoprogesterone
- 11-Dehydroprogesterone
- 11-Deoxycorticosterone
- 16α-Hydroxyprogesterone
- 17α-Methyl-11-deoxycorticosterone acetate
- 20α-Dihydroprogesterone
- 20β-Dihydroprogesterone
- Dimepregnen
- Diosgenin
- P1-185
- Progesterone
- Progesterone 3-acetyl enol ether
- Quingestrone
- Retroprogesterone derivatives: 20α-Dihydrodydrogesterone
- 20α-Dihydrotrengestone
- DU-41164
- DU-41165
- Dydrogesterone
- Retroprogesterone
- Ro 6-3129
- Trengestone
- 17α-Substituted progesterone derivatives: 6α-Methyl-17α-bromoprogesterone
- 15β-Hydroxycyproterone acetate
- 16-Methylene-17α-hydroxyprogesterone acetate
- 17α-Bromoprogesterone
- 17α-Hydroxyprogesterone (hydroxyprogesterone)
- 17α-Methylprogesterone
- Acetomepregenol (mepregenol diacetate)
- Algestone
- Algestone acetonide
- Algestone acetophenide
- Anagestone
- Anagestone acetate
- Bromethenmadinone
- Bromethenmadinone acetate
- Butagest (buterol)
- Chlormadinone
- Chlormadinone acetate
- Chlormadinone caproate
- Chlormethenmadinone
- Chlormethenmadinone acetate
- Cismadinone
- Cismadinone acetate
- Clogestone
- Clogestone acetate
- Clomegestone
- Clomegestone acetate
- Cymegesolate
- Cyproterone acetate
- Delmadinone
- Delmadinone acetate
- Edogestrone
- Flugestone
- Flugestone acetate
- Fluorometholone
- Fluorometholone acetate
- Flumedroxone
- Flumedroxone acetate
- Fluoromedroxyprogesterone acetate
- Gestaclone
- Gestobutanoyl
- Haloprogesterone
- Hydromadinone
- Hydromadinone acetate
- Hydroxyprogesterone acetate
- Hydroxyprogesterone caproate (hydroxyprogesterone hexanoate)
- Hydroxyprogesterone heptanoate (hydroxyprogesterone enanthate)
- Hydroxyprogesterone heptanoate benzilic acid hydrazone
- Mecigestone (pentarane B)
- Medrogestone
- Medroxyprogesterone
- Medroxyprogesterone acetate
- Medroxyprogesterone caproate
- Megestrol
- Megestrol acetate
- Megestrol caproate
- Melengestrol
- Melengestrol acetate
- Methenmadinone
- Methenmadinone acetate
- Methenmadinone caproate
- Mometasone
- Mometasone furoate
- Osaterone
- Osaterone acetate
- Pentagestrone
- Pentagestrone acetate
- Pentarane A
- Proligestone
- Triamcinolone acetonide
- 19-Norprogesterone derivatives: 17α-Methyl-19-norprogesterone
- 18-Methylsegesterone acetate
- 19-Norprogesterone
- Amadinone
- Amadinone acetate
- Demegestone
- Fluoro ethyl norprogesterone
- Fluoro furanyl norprogesterone
- Gestadienol
- Gestadienol acetate
- Gestonorone acetate (gestronol acetate)
- Gestonorone caproate (gestronol hexanoate)
- Gestronol (gestonorone)
- Nomegestrol
- Nomegestrol acetate
- Norgestomet
- ORG-2058
- Oxogestone
- Oxogestone phenpropionate (xinogestone)
- Promegestone
- Segesterone
- Segesterone acetate (nestorone)
- Trimegestone
- Testosterone derivatives: Progestins: 6,6-Difluoronorethisterone
- 6,6-Difluoronorethisterone acetate
- 17α-Allyl-19-nortestosterone
- Allylestrenol
- Altrenogest
- Chloroethynylnorgestrel
- Cingestol
- Danazol
- Desogestrel
- Dienogest
- Ethinylandrostenediol
- Ethisterone
- Ethynerone
- Etonogestrel
- Etynodiol
- Etynodiol diacetate
- Gestodene
- Gestrinone
- Levonorgestrel
- Levonorgestrel esters (e.g., levonorgestrel butanoate)
- Lynestrenol
- Lynestrenol phenylpropionate
- Metynodiol
- Metynodiol diacetate
- Norelgestromin
- Norethisterone (norethindrone)
- Norethisterone esters (e.g., norethisterone acetate, norethisterone enanthate)
- Noretynodrel
- Norgesterone
- Norgestimate
- Norgestrel
- Norgestrienone
- Norvinisterone
- Oxendolone
- Quingestanol
- Quingestanol acetate
- Tibolone
- Tigestol
- Tosagestin; Anabolic–androgenic steroids: 11β-Methyl-19-nortestosterone
- 11β-Methyl-19-nortestosterone dodecylcarbonate
- 19-Nor-5-androstenediol
- 19-Nor-5-androstenedione
- 19-Nordehydroepiandrosterone
- Bolandiol
- Bolandiol dipropionate
- Bolandione
- Dimethisterone
- Dienedione
- Dienolone
- Dimethandrolone
- Dimethandrolone buciclate
- Dimethandrolone dodecylcarbonate
- Dimethandrolone undecanoate
- Dimethyldienolone
- Dimethyltrienolone
- Ethyldienolone
- Ethylestrenol (ethylnandrol)
- Methyldienolone
- Metribolone (R-1881)
- Methoxydienone (methoxygonadiene)
- Mibolerone
- Nandrolone
- Nandrolone esters (e.g., nandrolone decanoate, nandrolone phenylpropionate)
- Norethandrolone
- Normethandrone (methylestrenolone, normethandrolone, normethisterone)
- RU-2309
- Tetrahydrogestrinone
- Trenbolone (trienolone)
- Trenbolone esters (e.g., trenbolone acetate, trenbolone enanthate)
- Trendione
- Trestolone
- Trestolone acetate
- Spirolactone derivatives: Canrenoic acid
- Canrenone
- Drospirenone
- Mespirenone
- Potassium canrenoate
- Prorenone
- SC-5233 (spirolactone)
- SC-8109
- Spironolactone
- Spirorenone
- Nonsteroidal: 3,8-Dihydrodiligustilide
- LG-2527
- LG-100128
- Riligustilide
- RWJ-26819
- RWJ-49853
- RWJ-60130
- Tanaproget
- ZM-182345
- Unknown: ORG-47241
- ORG-201745
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Mixed
(SPRMsTooltip Selective progesterone receptor modulators) | |
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| Antagonists | |
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mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor) | |
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