LGTN

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An Error has occurred retrieving Wikidata item for infobox Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene.[1][2] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.[2]

See also

References

  1. Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( Pt 2) (2): 227–32. doi:10.1242/jcs.93.2.227. PMID 2482295.
  2. 2.0 2.1 "Entrez Gene: LGTN ligatin".

Further reading