Mitochondrial ribosomal protein L13
An Error has occurred retrieving Wikidata item for infobox Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene. [1]
Function
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and play a crucial role in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) are composed of a small 28S subunit and a large 39S subunit, with an estimated protein to rRNA composition of 75% with contrasts with prokaryotic ribosomes, where this ratio is reversed. Another distinction between mammalian mitoribosomes and prokaryotic ribosomes is that the latter includes a 5S rRNA. The proteins that make up the mitoribosome vary significantly in sequence, and sometimes in biochemical properties across different species, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
References
- ↑ "Entrez Gene: Mitochondrial ribosomal protein L13". Retrieved 2017-07-05.
Further reading
- Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL (2008). "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression". Mol. Cell. 32 (3): 371–82. doi:10.1016/j.molcel.2008.09.019. PMC 2644327. PMID 18995835.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
