NLRC3
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An Error has occurred retrieving Wikidata item for infobox NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[1] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[2] NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.[3]
References
- ↑ Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
- ↑ Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
- ↑ Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. Bibcode:2016Natur.540..583K. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.
