RDH8
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An Error has occurred retrieving Wikidata item for infobox Retinol dehydrogenase 8 is an enzyme that in humans is encoded by the RDH8 gene.[1][2][3] All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH.[1] It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of the photoreceptor cells; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin.[4] This is a rate-limiting step in the visual cycle.[5][supplied by OMIM][3]
References
- ↑ 1.0 1.1 Rattner A, Smallwood PM, Nathans J (May 2000). "Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol". J Biol Chem. 275 (15): 11034–11043. doi:10.1074/jbc.275.15.11034. PMID 10753906.
- ↑ Persson B, Kallberg Y, Bray JE, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
- ↑ 3.0 3.1 "Entrez Gene: RDH8 retinol dehydrogenase 8 (all-trans)".
- ↑ Rando RR (2001). "The biochemistry of the visual cycle". Chem. Rev. 101 (7): 1881–1896. doi:10.1021/cr960141c. PMID 11710234.
- ↑ Saari JC, Garwin GG, Van Hooser JP, et al. (1998). "Reduction of all-trans-retinal limits regeneration of visual pigment in mice". Vision Res. 38 (10): 1325–1333. doi:10.1016/S0042-6989(97)00198-3. PMID 9667000. S2CID 16267177.
Further reading
- Maeda A, Maeda T, Imanishi Y, et al. (2005). "Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo". J. Biol. Chem. 280 (19): 18822–18832. doi:10.1074/jbc.M501757200. PMC 1283069. PMID 15755727.
- Perrault I, Hanein S, Gerber S, et al. (2004). "Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis". Am. J. Hum. Genet. 75 (4): 639–646. doi:10.1086/424889. PMC 1182050. PMID 15322982.
- Luo W, Marsh-Armstrong N, Rattner A, et al. (2004). "An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase". J. Neurosci. 24 (11): 2623–2632. doi:10.1523/JNEUROSCI.5302-03.2004. PMC 6729528. PMID 15028754.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Haeseleer F, Jang GF, Imanishi Y, et al. (2003). "Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina". J. Biol. Chem. 277 (47): 45537–45546. doi:10.1074/jbc.M208882200. PMC 1435693. PMID 12226107.
