Transmembrane protein 151b
An Error has occurred retrieving Wikidata item for infobox Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene.[1]
Nomenclature
The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.[2]
Gene
The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs.[3] It is a complex locus that contains both TMEM151B and SPATS1.[4] TMEM151B has one paralog: TMEM151A.[5]
Transcript
The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp.[3]
Protein
The protein has a length of 566 amino acids and contains two transmembrane domains.[2] According to Compute pI/Mw, molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72.[7][2] The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor.[8]
Expression
RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes.[10] NCBI geo profiles similarly show localization to the brain tissues.[11] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas.[9]
Protein interactions
The TMEM151B protein interacts with one other protein according to BioGRID.[12]
- SREBF2- a transcription factor precursor which is imbedded in the endoplasmic reticulum membrane; activates genes involved with cholesterol biosynthesis.[13]
Homology and evolution
The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B.[5][14] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c.[5][15]
Research
Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer.[16] It was also found to be up-regulated in post-menopausal breast cancer.[17][18] A SNP found within TMEM151B is associated with the development of lean muscle.[19]
References
- ↑ "Entrez Gene: Transmembrane protein 151B".
- ↑ 2.0 2.1 2.2 "transmembrane protein 151B [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
- ↑ 3.0 3.1 "Homo sapiens transmembrane protein 151B (TMEM151B), mRNA - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-09-29.
- ↑ "AceView: Gene:TMEM151BandSPATS1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2021-10-04.
- ↑ 5.0 5.1 5.2 5.3 "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ↑ "Protter - interactive protein feature visualization". wlab.ethz.ch. Retrieved 2022-01-13.
- ↑ "ExPASy - Compute pI/Mw tool". web.expasy.org. Retrieved 2022-01-13.
- ↑ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
- ↑ 9.0 9.1 "ISH Data :: Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2022-01-13.
- ↑ "TMEM151B transmembrane protein 151B [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ↑ "GDS596 / 213678_at". www.ncbi.nlm.nih.gov. Retrieved 2022-01-13.
- ↑ "TMEM151B (RP11-444E17.5) Result Summary | BioGRID". thebiogrid.org. Retrieved 2022-01-13.
- ↑ "SREBF2 Gene - GeneCards | SRBP2 Protein | SRBP2 Antibody". www.genecards.org. Retrieved 2022-01-13.
- ↑ "Clustal Omega < Multiple Sequence Alignment < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-01-13.
- ↑ "TimeTree :: The Timescale of Life". www.timetree.org. Retrieved 2022-01-13.
- ↑ Liu J, Li H, Shen S, Sun L, Yuan Y, Xing C (2018). "Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer". Journal of Cancer. 9 (10): 1754–1764. doi:10.7150/jca.24569. PMC 5968763. PMID 29805701.
- ↑ Carter JM, Nair AA, Davila JI, Heinzen EP, Hoskin TL, Winham SJ, et al. (2019-02-15). "Abstract P3-08-10: A unique coding and non-coding benign breast transcriptome in post-menopausal ER+ breast cancer". Poster Session Abstracts. 79 (4_Supplement). American Association for Cancer Research. doi:10.1158/1538-7445.sabcs18-p3-08-10. S2CID 164377723.
- ↑ Qian D, Zheng Q, Wu D, Ye B, Qian Y, Zhou T, et al. (2021-05-13). "Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer". Frontiers in Oncology. 11: 670138. doi:10.3389/fonc.2021.670138. PMC 8158160. PMID 34055638.
- ↑ Pei YF, Hu WZ, Yang XL, Wei XT, Feng GJ, Zhang H, et al. (November 2019). "Two functional variants at 6p21.1 were associated with lean mass". Skeletal Muscle. 9 (1): 28. doi:10.1186/s13395-019-0212-3. PMC 6874818. PMID 31757224.
