Liudmila Samsonova defeated Kaia Kanepi in the final, 4–6, 6–3, 6–3 to win the women's singles tennis title at the 2022 Washington Open.[1] Kanepi was aiming to win her first title since 2013, and to be the oldest player to win a WTA Tour title since Serena Williams in 2020.
Jessica Pegula was the defending champion from when the event was last held in 2019,[2] but lost in the second round to Daria Saville.[3]